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«MODULATION OF POLYAMINE METABOLISM AS A CHEMOPREVENTIVE STRATEGY OF PHYTOCHEMICALS IN A CELL CULTURE MODEL OF COLORECTAL CANCERS Dissertation zur ...»

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Ducharme,M.P. (2002) Metabolism and disposition of resveratrol in rats:

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189. Kaldas,M.I., Walle,U.K., and Walle,T. (2003) Resveratrol transport and metabolism by human intestinal Caco-2 cells. J.Pharm.Pharmacol., 55, 307-312.

190. Lancon,A., Delma,D., Osman,H., Thenot,J.P., Jannin,B., and Latruffe,N.

(2004) Human hepatic cell uptake of resveratrol: involvement of both passive diffusion and carrier-mediated process.

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191. Goldberg,D.M., Yan,J., and Soleas,G.J. (2003) Absorption of three winerelated polyphenols in three different matrices by healthy subjects.

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199. Liao,Q., Yang,W., Jia,Y., Chen,X., Gao,Q., and Bi,K. (2005) LC-MS determination and pharmacokinetic studies of ursolic acid in rat plasma after administration of the traditional chinese medicinal preparation LuYing extract. Yakugaku Zasshi, 125, 509-515.

200. Andersson,D., Cheng,Y., and Duan,R.D. (2007) Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin

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201. Gescher,A.J. and Steward,W.P. (2003) Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: a conundrum. Cancer Epidemiol.Biomarkers Prev., 12, 953Pervaiz,S. (2003) Resveratrol: from grapevines to mammalian biology.

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205. Mertens-Talcott,S.U. and Percival,S.S. (2005) Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Lett., 218, 141-151.

206. Chan,M.M., Mattiacci,J.A., Hwang,H.S., Shah,A., and Fong,D. (2000) Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway. Biochem.Pharmacol., 60, 1539-1548.





207. Fang,J.G., Lu,M., Chen,Z.H., Zhu,H.H., Li,Y., Yang,L., Wu,L.M., and Liu,Z.L. (2002) Antioxidant effects of resveratrol and its analogues against the free-radical-induced peroxidation of linoleic acid in micelles.

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208. Bhat,K.P., Lantvit,D., Christov,K., Mehta,R.G., Moon,R.C., and Pezzuto,J.M. (2001) Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res., 61, 7456-7463.

209. Tessitore,L., Davit,A., Sarotto,I., and Caderni,G. (2000) Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression. Carcinogenesis, 21, 1619-1622.

210. Banerjee,S., Bueso-Ramos,C., and Aggarwal,B.B. (2002) Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res., 62, 4945-4954.

211. Li,Z.G., Hong,T., Shimada,Y., Komoto,I., Kawabe,A., Ding,Y., Kaganoi,J., Hashimoto,Y., and Imamura,M. (2002) Suppression of Nnitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol. Carcinogenesis, 23, 1531-1536.

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defense-related gene expression in an animal model of human familial adenomatous polyposis. Nutr.Cancer, 39, 102-107.

213. Dorai,T. and Aggarwal,B.B. (2004) Role of chemopreventive agents in cancer therapy. Cancer Lett., 215, 129-140.

214. Yu,L., Wu,S.L., Zhang,M., and Pan,C.E. (2003) [Effect of resveratrol alone and its combination with cyclosporin A on the immune function of human peripheral blood T lymphocytes]. Xi.Bao.Yu Fen.Zi.Mian.Yi.Xue.Za Zhi., 19, 549-551.

215. Kubota,T., Uemura,Y., Kobayashi,M., and Taguchi,H. (2003) Combined effects of resveratrol and paclitaxel on lung cancer cells. Anticancer Res., 23, 4039-4046.

216. Sun,Z.J., Pan,C.E., Liu,H.S., and Wang,G.J. (2002) Anti-hepatoma activity of resveratrol in vitro. World J.Gastroenterol., 8, 79-81.

217. Wu,S.L., Sun,Z.J., Yu,L., Meng,K.W., Qin,X.L., and Pan,C.E. (2004) Effect of resveratrol and in combination with 5-FU on murine liver cancer.

World J.Gastroenterol., 10, 3048-3052.

218. Rezk,Y.A., Balulad,S.S., Keller,R.S., and Bennett,J.A. (2006) Use of

resveratrol to improve the effectiveness of cisplatin and doxorubicin:

study in human gynecologic cancer cell lines and in rodent heart.

Am.J.Obstet.Gynecol., 194, e23-e26.

219. Shankar,S., Siddiqui,I., and Srivastava,R.K. (2007) Molecular mechanisms of resveratrol (3,4,5-trihydroxy-trans-stilbene) and its interaction with TNF-related apoptosis inducing ligand (TRAIL) in androgen-insensitive prostate cancer cells. Mol.Cell Biochem..

220. Fulda,S. and Debatin,K.M. (2004) Sensitization for tumor necrosis factorrelated apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol. Cancer Res., 64, 337-346.

221. Sale,S., Verschoyle,R.D., Boocock,D., Jones,D.J., Wilsher,N., Ruparelia,K.C., Potter,G.A., Farmer,P.B., Steward,W.P., and Gescher,A.J. (2004) Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4'-tetramethoxystilbene. Br.J.Cancer, 90, 736-744.

222. Roberti,M., Pizzirani,D., Simoni,D., Rondanin,R., Baruchello,R., Bonora,C., Buscemi,F., Grimaudo,S., and Tolomeo,M. (2003) Synthesis and biological evaluation of resveratrol and analogues as apoptosisinducing agents. J.Med.Chem., 46, 3546-3554.

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B., STEIN, J. (2005) Activation of PPARγ is not involved in butyrateinduced epithelial cell differentiation. Exp Cell Res 310(1): 196-204.

2. ULRICH, S., LOITSCH, S., RAU O., VON KNETHEN, A., BRÜNE, B., SCHUBERTZSILAVECZ, M., STEIN, J. (2006) Peroxisome-Proliferator activated receptor γ as a molecular target of resveratrol-induced modulation of polyamine metabolism. Cancer Res 66(14): 7348-54.

3. SCHWAB, M., REYNDERS, V., ULRICH, S., ZAHN, N., STEIN, J., SCHRÖDER, N.

(2006) PPARγ is a key target of butyrate-induced caspase-3 activation in the colorectal cancer cell line Caco-2. Apoptosis 11(10): 1801-11.

4. ULRICH, S., HUWILER, A., LOITSCH, S., SCHMIDT, H., STEIN J. (2007) De novo ceramide biosynthesis is assaociated with resveratrol-induced

inhibition of ornithine decarboxylase activity. Biochem Pharmacol 74(2):

281-9.

5. ULRICH, S., JUNG, B., LOITSCH, S., KAMPAN, W., STEIN, J. (2007) Ursolic acid induces apoptosis through PPARγ mediated SSAT-activation in colon cancer cells (submitted)

ÜBERSICHTSARBEITEN

1. WOLTER, F., ULRICH, S., STEIN, J. (2004) Molecular mechanisms of the chemopreventive effects of resveratrol and its analogs in colorectal cancer: key role of polyamines. J Nutr 134(12): 3219-22. Review

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2. ULRICH, S., WOLTER, F., STEIN, J. (2005) Molecular mechanisms of the chemopreventive effects of resveratrol and its analogs in carcinogenesis.

Mol Nutr Food Res 49(5): 452-61. Review VORTRÄGE I. Ulrich, S., Loitsch, S., Huwiler, A., Rau, O., Stein, J. “Resveratrol modulates polyamine metabolism of colorectal cancer cells via two different signal transduction pathways”, anlässlich der 2nd International Conference on Polyphenols and Health, Davis, CA, October 4-7, 2005 II. Ulrich, S., Jung, B., Buettner, S., Stein, J (2006) “Molecular characterization of the chemopreventive activity of pentacyclic triterpene ursolic acid”, anlässlich der Digestive Disease Week, Los Angeles, CA, May 20-25, 2006 III. Ulrich, S., Huwiler, A., Loitsch, S., Schmidt, H., Stein, J. (2006) „De novo ceramide biosynthesis is involved in resveratrol-induced inhibition of ornithine decarboxylase activity”, anlässlich der 3rd International Conference on Polyphenols Applications in Nutrition and Health, Malta, October 26-27, 2006 IV. Ulrich, S., Büttner, S., Stein, J. (2007) “Molecular characterization of the anti-angiogenic properties of the pentacyclic triterpene ursolic acid, anlässlich der Digestive Disease Week, Washington, DC, May 19-24, V. Ulrich, S., Kampan, W., Stein, J. (2007) “Resveratrol sensitizes colorectal cancer cells to oxaliplatin-induced cell growth inhibition”, anlässlich der Digestive Disease Week, Washington, DC, May 19-24,

–  –  –

KONGRESSBEITRÄGE/ABSTRACTS

1. Ulrich, S., Wächtershäuser, A., Gaschott, T., Stein, J.

Die Butyrat-induzierte PPARγ-Expression ist nicht mit epithelialer Zelldifferenzierung assoziiert; Z Gastroenterol (2003) 41:764

58. Jahrestagung der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten, Nürnberg, September 17-20, 2003

2. Ulrich, S., Stein, J.

Die Butyrat-induzierte Steigerung der Spermin/SpermidinAcetyltransferase (SSAT) Aktivität wird über den Transkriptionsfaktor PPARγ vermittelt; Akt Ern Med (2004) 29(2) Nutrition 2004, Munich, May 6-8, 2004

3. Ulrich, S., Wächtershäuser, A., Loitsch, S., Gaschott, T., Stein, J.

Butyrate-induced PPARγ expression is not associated with epithelial cell differentiation; Gastroenterology 2004; 126 (4), Suppl.2 Digestive Disease Week, New Orleans, May 15-20, 2004

4. Ulrich, S., Huwiler, A., Wolter, F., Loitsch, S., Stein, J.

Resveratrol moduliert den Polyaminstoffwechsel kolorektaler Karzinomzellen über zwei unterschiedliche Signaltransduktionswege;

Z Gastroenterol 2004; 42(8):903

59. Jahrestagung der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten, Leipzig, September 1-4, 2004

–  –  –

polyphenols ZAFES Kick-off symposium “Lipid signaling”, Frankfurt/Main, October 14, 2004

7. Ulrich, S., Wächtershäuser, A., Caspary, W.F., Stein J.

Statins – from cardioprotection to colorectal cancer prevention ZAFES Kick-off symposium “Lipid signaling”, Frankfurt/Main, October 14, 2004

8. Ulrich, S., Wolter, F., Loitsch, S., Stein, J.

The phytoalexin resveratrol induces inhibition of ornithine decarboxylase via a ceramide signaling pathway 3rd International Symposium on PPARs, Monte Carlo, March 29-23, 2005

9. Daniel, C., Ulrich, S., Hagos, M., Loitsch, S., Stein, J.

Ursolic acid increases spermine/spermidine acetyltransferase activity in colorectal cancer cells via PPARγ signaling pathway 3rd International Symposium on PPARs, Monte Carlo, March 29-23, 2005

10. Ulrich, S., Wolter, F., Loitsch, S., Stein, J.

PPARγ fungiert als molekulares Target in der Resveratrol-vermittelten Modulation des Polyaminstoffwechsels Jahrestagung der Mitteldeutschen Gesellschaft für Gastroenterologie, Bad Nauheim, May 5-7, 2005

11. Ulrich, S., Hagos, M., Loitsch, S., Stein, J.



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