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«3. Medizinische Klinik und Poliklinik – Hämatologische Forschung Cks1 is a critical regulator of hematopoietic stem cell cycling, quiescence and ...»

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62. Rossi, L., et al., Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice. Cell Stem Cell, 2012.

11(3): p. 302-17.

63. Brenet, F., et al., TGFbeta restores hematopoietic homeostasis after myelosuppressive chemotherapy. J Exp Med, 2013. 210(3): p. 623-39.

64. Blank, U., et al., Smad7 promotes self-renewal of hematopoietic stem cells. Blood, 2006. 108(13): p. 4246-54.

65. Yamazaki, S., et al., Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells. EMBO J, 2006. 25(15): p. 3515-23.

66. Yamazaki, S., et al., TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. Blood, 2009. 113(6): p.

1250-6.

REFERENCES

67. Yamazaki, S., et al., Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell, 2011. 147(5): p. 1146-58.

68. Karlsson, G., et al., Smad4 is critical for self-renewal of hematopoietic stem cells. J Exp Med, 2007. 204(3): p. 467-74.

69. Guo, W., et al., Multi-genetic events collaboratively contribute to Ptennull leukaemia stem-cell formation. Nature, 2008. 453(7194): p. 529-33.

70. Yilmaz, O.H., et al., Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature, 2006. 441(7092): p. 475-82.

71. Zhang, J., et al., PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature, 2006. 441(7092): p.

518-22.

72. Juntilla, M.M., et al., AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. Blood, 2010. 115(20): p.

4030-8.

73. Miyamoto, K., et al., Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell, 2007. 1(1): p. 101-12.

74. Tothova, Z., et al., FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell, 2007. 128(2): p. 325Peifer, M. and P. Polakis, Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus. Science, 2000. 287(5458): p.

1606-9.

76. Fleming, H.E., et al., Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.

Cell Stem Cell, 2008. 2(3): p. 274-83.

77. Zhao, C., et al., Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell, 2007. 12(6): p. 528-41.

78. Sugimura, R., et al., Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell, 2012. 150(2): p. 351-65.

79. Cheshier, S.H., et al., In vivo proliferation and cell cycle kinetics of longterm self-renewing hematopoietic stem cells. Proc Natl Acad Sci U S A, 1999. 96(6): p. 3120-5.

REFERENCES

80. Steinman, R.A., Cell cycle regulators and hematopoiesis. Oncogene, 2002. 21(21): p. 3403-13.

81. Pietras, E.M., M.R. Warr, and E. Passegue, Cell cycle regulation in hematopoietic stem cells. Journal of Cell Biology, 2011. 195(5): p. 709Passegue, E., et al., Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med, 2005. 202(11): p. 1599-611.

83. Kozar, K., et al., Mouse development and cell proliferation in the absence of D-cyclins. Cell, 2004. 118(4): p. 477-91.

84. Sasaki, K. and Y. Sonoda, Histometrical and three-dimensional analyses of liver hematopoiesis in the mouse embryo. Arch Histol Cytol, 2000.

63(2): p. 137-46.

85. Jones, R.J., et al., Separation of pluripotent haematopoietic stem cells from spleen colony-forming cells. Nature, 1990. 347(6289): p. 188-9.

86. Malumbres, M., et al., Mammalian cells cycle without the D-type cyclindependent kinases Cdk4 and Cdk6. Cell, 2004. 118(4): p. 493-504.

87. Berthet, C., et al., Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2. Mol Cell Biol, 2007. 27(14): p. 5079-89.

88. Cobrinik, D., et al., Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev, 1996. 10(13): p. 1633-44.

89. LeCouter, J.E., et al., Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene. Mol Cell Biol, 1998. 18(12): p. 7455-65.

90. Walkley, C.R. and S.H. Orkin, Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells. Proc Natl Acad Sci U S A, 2006. 103(24): p. 9057-62.

91. Viatour, P., et al., Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell, 2008. 3(4): p. 416-28.

92. Yuan, Y., et al., In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C. Nat Cell Biol, 2004. 6(5): p. 436-42.

REFERENCES

93. Stepanova, L. and B.P. Sorrentino, A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress.





Blood, 2005. 106(3): p. 827-32.

94. Cheng, T., et al., Hematopoietic stem cell quiescence maintained by p21(cip1/waf1). Science, 2000. 287(5459): p. 1804-1808.

95. Van Os, R., et al., A limited role for p21(Cip1/Waf1) in maintaining normal hematopoietic stem cell functioning. Stem Cells, 2007. 25(4): p.

836-843.

96. Foudi, A., et al., Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nature Biotechnology, 2009. 27(1): p.

84-90.

97. Cheng, T., et al., Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science, 2000. 287(5459): p. 1804-8.

98. van Os, R., et al., A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning. Stem Cells, 2007. 25(4): p. 836-43.

99. Cheng, T., et al., Stem cell repopulation efficiency but not pool size is governed by p27(kip1). Nature Medicine, 2000. 6(11): p. 1235-1240.

100. Matsumoto, A., et al., p57 is required for quiescence and maintenance of adult hematopoietic stem cells. Cell Stem Cell, 2011. 9(3): p. 262-71.

101. Zou, P., et al., p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70. Cell Stem Cell, 2011. 9(3): p. 247-61.

102. Scandura, J.M., et al., Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation.

Proc Natl Acad Sci U S A, 2004. 101(42): p. 15231-6.

103. Heisterkamp, N., et al., Structural organization of the bcr gene and its role in the Ph' translocation. Nature, 1985. 315(6022): p. 758-61.

104. le Coutre, P., et al., Nilotinib (formerly AMN107), a highly selective BCRABL tyrosine kinase inhibitor, is active in patients with imatinib-resistant or -intolerant accelerated-phase chronic myelogenous leukemia. Blood, 2008. 111(4): p. 1834-9.

105. Nowell, P.C. and D.A. Hungerford, Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst, 1960. 25: p. 85-109.

REFERENCES

106. Rowley, J.D., Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature, 1973. 243(5405): p. 290-3.

107. Goldman, J.M., Chronic myeloid leukemia: a historical perspective.

Semin Hematol, 2010. 47(4): p. 302-11.

108. Chen, Y., et al., Molecular and cellular bases of chronic myeloid leukemia. Protein Cell, 2010. 1(2): p. 124-32.

109. Calabretta, B. and D. Perrotti, The biology of CML blast crisis. Blood, 2004. 103(11): p. 4010-22.

110. Kantarjian, H.M., et al., Chronic myelogenous leukemia in blast crisis.

Analysis of 242 patients. Am J Med, 1987. 83(3): p. 445-54.

111. Hamad, A., et al., Emerging therapeutic strategies for targeting chronic myeloid leukemia stem cells. Stem Cells Int, 2013. 2013: p. 724360.

112. Druker, B.J., et al., Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med, 1996. 2(5): p.

561-6.

113. Druker, B.J., et al., Efficacy and safety of a specific inhibitor of the BCRABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med, 2001.

344(14): p. 1031-7.

114. Corbin, A.S., et al., Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. J Clin Invest, 2011. 121(1): p. 396-409.

115. Nicholson, E. and T. Holyoake, The chronic myeloid leukemia stem cell.

Clin Lymphoma Myeloma, 2009. 9 Suppl 4: p. S376-81.

116. Graham, S.M., et al., Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood, 2002. 99(1): p. 319-25.

117. Hadwiger, J.A., et al., The Saccharomyces cerevisiae CKS1 gene, a homolog of the Schizosaccharomyces pombe suc1+ gene, encodes a subunit of the Cdc28 protein kinase complex. Mol Cell Biol, 1989. 9(5): p.

2034-41.

118. Hayles, J., et al., The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function. Mol Gen Genet, 1986. 202(2): p. 291-3.

REFERENCES

119. Brizuela, L., G. Draetta, and D. Beach, p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase. EMBO J, 1987. 6(11): p. 3507-14.

120. Bourne, Y., et al., Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. Cell, 1996. 84(6): p. 863-74.

121. Tang, Y. and S.I. Reed, The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae. Genes Dev, 1993. 7(5): p.

822-32.

122. Patra, D. and W.G. Dunphy, Xe-p9, a Xenopus Suc1/Cks homolog, has multiple essential roles in cell cycle control. Genes Dev, 1996. 10(12): p.

1503-15.

123. Richardson, H.E., et al., Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. Genes Dev, 1990. 4(8): p. 1332-44.

124. Martinsson-Ahlzen, H.S., et al., Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells. Mol Cell Biol, 2008. 28(18): p.

5698-709.

125. Harper, J.W., Protein destruction: adapting roles for Cks proteins. Curr Biol, 2001. 11(11): p. R431-5.

126. Wolthuis, R., et al., Cdc20 and Cks direct the spindle checkpointindependent destruction of cyclin A. Mol Cell, 2008. 30(3): p. 290-302.

127. Kaiser, P., et al., Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets. Genes Dev, 1999. 13(9): p. 1190-202.

128. Spruck, C., et al., A CDK-independent function of mammalian Cks1:

targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. Mol Cell, 2001.

7(3): p. 639-50.

129. Lecker, S.H., A.L. Goldberg, and W.E. Mitch, Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol, 2006. 17(7): p. 1807-19.

130. Ho, M.S., P.I. Tsai, and C.T. Chien, F-box proteins: the key to protein degradation. J Biomed Sci, 2006. 13(2): p. 181-91.

REFERENCES

131. Pickart, C.M. and M.J. Eddins, Ubiquitin: structures, functions, mechanisms. Biochim Biophys Acta, 2004. 1695(1-3): p. 55-72.

132. Petroski, M.D. and R.J. Deshaies, Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol, 2005. 6(1): p. 9-20.

133. Krek, W., Proteolysis and the G1-S transition: the SCF connection. Curr Opin Genet Dev, 1998. 8(1): p. 36-42.

134. Carrano, A.C., et al., SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol, 1999. 1(4): p. 193-9.

135. Ganoth, D., et al., The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol, 2001. 3(3): p.

321-4.

136. Bartek, J. and J. Lukas, p27 destruction: Cks1 pulls the trigger. Nat Cell Biol, 2001. 3(4): p. E95-8.

137. Sitry, D., et al., Three different binding sites of Cks1 are required for p27ubiquitin ligation. J Biol Chem, 2002. 277(44): p. 42233-40.

138. Yao, Z.P., et al., Activation of ubiquitin ligase SCF(Skp2) by Cks1:

insights from hydrogen exchange mass spectrometry. J Mol Biol, 2006.

363(3): p. 673-86.

139. Yu, Z.K., J.L.M. Gervais, and H. Zhang, Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins. Proceedings of the National Academy of Sciences of the United States of America, 1998. 95(19): p. 11324-11329.

140. Bornstein, G., et al., Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J Biol Chem, 2003. 278(28): p.

25752-7.

141. Kamura, T., et al., Degradation of p57(Kip2) mediated by SCFSkp2 dependent ubiquitylation. Proceedings of the National Academy of Sciences of the United States of America, 2003. 100(18): p. 10231Tedesco, D., J. Lukas, and S.I. Reed, The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the proteinubiquitin ligase SCFSkp2. Genes Dev, 2002. 16(22): p. 2946-2957.

REFERENCES

143. Westbrook, L., et al., Cks1 regulates cdk1 expression: A novel role during mitotic entry in breast cancer cells. Cancer Research, 2007.

67(23): p. 11393-11401.

144. Hoellein, A., et al., Cks1 Promotion of S Phase Entry and Proliferation Is Independent of p27(Kip1) Suppression. Molecular and Cellular Biology, 2012. 32(13): p. 2416-2427.



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