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«3. Medizinische Klinik und Poliklinik – Hämatologische Forschung Cks1 is a critical regulator of hematopoietic stem cell cycling, quiescence and ...»

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174. Ema, H., et al., In vitro self-renewal division of hematopoietic stem cells.

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180. Randall, T.D. and I.L. Weissman, Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment. Blood, 1997. 89(10): p. 3596-606.

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182. Hao, B., et al., Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol Cell, 2005. 20(1): p. 9Soeiro, I., et al., p27Kip1 and p130 cooperate to regulate hematopoietic cell proliferation in vivo. Mol Cell Biol, 2006. 26(16): p. 6170-84.

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222. Wu, J., et al., Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex. Oncogene, 2013. 32(1): p. 78-85.

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–  –  –

9. Publications

1. Höglund A, Nilsson LM, Muralidharan SV, Hasvold LA, Merta P, Rudelius M, Nikolova V, Keller U, Nilsson JA (2011) “Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer cells”. Clin Cancer Res; 17 (22):7067-79.

2. Kratzat S, Nikolova V, Miething C, Hoellein A, Schoeffmann S, Gorka O, Pietschmann E, Illert AL, Ruland J, Peschel C, Nilsson J, Duyster J, Keller U (2012) “Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies.” PLos ONE; 7(5):e37433.

3. Baumann U, Fernández-Sáiz V, Lemeer S, Rudelius M, Engel K, Tomiatti V, Targosz B, Knorn A, Braun M, Perner S, Klapper S, Dreyling M, Miething C, Leitges M, Peschel C, Keller U, Kuster B and Florian Bassermann “PKCδ directs SCFFbxo25 mediated degradation of Hax-1 to regulate cell survival and suppress lymphomagenesis” Submitted Manuscript.

4. Tomiatti V, Pietschmann E, Kratzat S, Hoellein A, Quintanilla-Fend L, von Bubnoff N, Peschel C, Oostendorp R, and Keller U “Cks1 is a critical regulator of hematopoietic stem cell cycling, quiescence and homeostasis, operating upstream of Cdk inhibitors” Submitted Manuscript.

–  –  –

10. Acknowledgements Numerous people have supported me during this project with their help, knowledge and encouragement and I feel very grateful for all their support.

There are some people who I would especially like to point out.

My gratitude goes out to Prof. Dr. Ulrich Keller for letting me join his group and allowing me to produce this thesis under his supervision. Also, I would like to thank Prof. Dr. Christian Peschel, director of the III. Medical Clinic at the Klinikum Rechts der Isar. The scientific environment there was important for succeeding with the project.

Especially, I wish to thank my mentor, PD Dr. Robert Oostendorp. He was advising me on my experiments and I learned a lot from him. The discussions with Robert were extremely helpful for the evaluation of the results.

I would like to thank Prof. Dr. Angelika Schnieke for accepting to become my second adviser, thus allowing me to complete my dissertation as a member of the medical graduate center.

I wish to thank all of my colleagues for the friendly and productive atmosphere in the lab. Especially I would like to thank Susanne and Steffi who were always willing to help me with experiments. Working with Madlen and Susanne made the work days more pleasant. Special thank goes to Susanne and Alex for proofreading my dissertation.

I wish to express my deepest gratitude to my parents, Pavlina and Georgi and my brother, Hristo. They supported me and believed in me through all the years of studying and working abroad.

Finally, I would like to thank my loving husband, Sebastian. His support gave

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