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«Signature: _ Stephen Wilson Date Synthesis and Reactivity of Benzo[1,3,2]dithiazole 1,1-dioxides: Implications in Acylative Redox Dehydration By ...»

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6.5 Hz, 1H), 1.10 (d, J = 6.5 Hz, 6H); 13C NMR (100 MHz, CDCl3) δ 147.5, 146.7, 134.7, 128.0, 123.1, 118.6, 57.1, 19.2; HRMS (ESI) Calcd for C9H10NaN2O4S2 [M+Na+] 296.9974, found 296.9973 42 6-nitro-2-phenyl-2H-benzo[d][1,3,2]dithiazole 1,1-dioxide. Following method A, from 2benzylthio)-5-nitro-N-phenylbenzenesulfonamide (4.72 g, 11.8 mmol) and sulfuryl chloride (1.14 mL, 14.1 mmol) was obtained clean prodouct after recrystallization from ethanol. Yellow solid (2.55 g, 8.3 mmol, 70 % yield); m.p. 234 oC (decomposed); 1H NMR (400 MHz, CDCl3) δ 9.06 – 8.89 (m, 1H), 8.80 (ddd, J = 8.5, 2.0, 0.9 Hz, 1H), 8.42 – 8.23 (m, 1H), 7.77 – 7.54 (m, 5H); 13C NMR (100 MHz, DMSO-d6) δ 152.4, 138.3, 135.8, 132.8, 132.3, 131.9, 131.2, 126.0, 124.6, 120.4; HRMS (ESI) Calcd for C12H8KN2O4S2 [M+K+] 346.8762, found 346.8834 2-(2,6-dimethylphenyl)-6-nitro-2H-benzo[d][1,3,2]dithiazole 1,1-dioxide. Following method A, from 2-(benzylthio)-N-(2,6-dimethylphenyl)-5-nitrobenzenesulfonamide (2.40 g, 5.6 mmol) and sulfuryl chloride (0.54 mL, 6.7 mmol) was obtained clean product after recrystallization from ethanol. Yellow solid (1.23 g, 3.7 mmol, 65 % yield); m.p. 239 - 241 oC; 1H NMR (400 MHz, DMSO-d6) δ 8.73 (d, J = 2.2 Hz, 1H), 8.53 (dd, J = 8.9, 2.2 Hz, 1H), 8.20 (d, J = 8.9 Hz, 1H), 7.26 (dd, J = 8.3, 6.7 Hz, 1H), 7.18 (d, J = 7.1 Hz, 2H), 2.14 (s, 6H); 13C NMR (75 MHz, DMSO-d6) δ 146.7, 144.9, 140.2, 134.2, 130.9, 130.5, 129.7, 128.0, 125.5, 118.5, 18.6; HRMS (ESI) Calcd for C14H12NaN2O4S2 [M+Na+] 359.0131, found 359.0131

–  –  –

To a dry round bottom flask was added BDT (1.0 equiv) and the flask was evacuated and backfilled with argon. Dry ethanol (0.20 M) was added and the flask cooled in an ice bath. As a solid in one portion was added sodium borohydride (4.0 equiv) and the reaction was stirred in the ice bath until completion as indicated by TLC. Upon completion, the product was precipitated by addition of 1M HCl, collected by filtration, and used as obtained without further purification.

The crude thiol (1.0 equiv) was added to a round bottom flask and taken up in DMSO (0.50 M) and MoO2Cl2DMSO2 (10 mol %, prepared as previously described32) was added to the flask as a solid in one portion. The reaction was stirred at room temperature until completion as indicated by TLC. Upon completion, water was added to the reaction to precipitate the disulfide which was collected by vacuum filtration, washed with water, and dried overnight. When necessary, the product was purified by recrystallization from ethanol or ethanol and water.

6,6'-disulfanediylbis(N-isopropyl-3-nitrobenzenesulfonamide). Following general procedure, from 2-isopropyl-6-nitro-2H-benzo[d][1,3,2]dithiazole 1,1-dioxide (2.00 g, 7.3 mmol), sodium borohydride (1.10 g, 29.2 mmol) and MoO2Cl2DMSO2 (0.30 g, 0.7 mmol) was obtained clean product without further purification. Yellow solid (1.53 g, 2.8 mmol, 76 % yield over 2 steps);

m.p. 184 - 187 oC; 1H NMR (400 MHz, DMSO-d6) δ 8.57 (dd, J = 2.5, 1.1 Hz, 1H), 8.51 (d, J =

8.0 Hz, 1H), 8.34 (ddd, J = 8.8, 2.5, 1.1 Hz, 1H), 8.01 (dd, J = 8.8, 1.1 Hz, 1H), 3.50 – 3.35 (m,

–  –  –

127.2, 124.3, 45.8, 23.3; HRMS (ESI) Calcd for C18H22NaN4O8S4 [M+Na+] 573.0213, found 573.0212; IR (neat) 3338, 3292 cm-1 6,6'-disulfanediylbis(3-nitro-N-phenylbenzenesulfonamide). Following general procedure from 6-nitro-2-phenyl-2H-benzo[d][1,3,2]dithiazole 1,1-dioxide (0.20 g, 0.7 mmol), sodium borohydride (0.10 g, 2.6 mmol) and MoO2Cl2DMSO2 (0.02 g, 0.1 mmol) was obtained clean product after recrystallization from ethanol. Pale yellow solid (0.11 g, 0.2 mmol, 55 % yield);

m.p. 255 - 258 oC (decomposed); 1H NMR (600 MHz, DMSO-d6) δ 11.11 (s, 1H), 8.57 (d, J =

2.4 Hz, 1H), 8.17 - 8.00 (m, 1H), 7.69 (d, J = 8.9 Hz, 1H), 7.27 (t, J = 7.7 Hz, 2H), 7.10 (d, J =

8.2 Hz, 3H); 13C NMR (151 MHz, DMSO-d6) δ 146.1, 141.8, 137.9, 136.1, 129.6, 128.1, 127.8, 125.2, 125.1, 120.7; HRMS (ESI) Calcd for C24H18NaN4O8S4 [M+Na+] 640.9900, found 640.9900; IR (neat) 3222 cm-1

General procedure for thioesterification:

To a dry round bottom flask was added BDT (1.0 equiv), carboxylic acid (1.0 equiv) and 4Å molecular sieves and the flask was evacuated and backfilled with argon. Dry toluene was added followed by either triphenylphosphine or triethylphosphite (1.0 equiv) and the reaction was

–  –  –

removed under reduced pressure and the crude residue was purified by flash column chromatography on silica gel to give the desired product thioesters.

S-(2-(N-phenylsulfamoyl)phenyl) 2-((tert-butoxycarbonyl)amino)-3-phenylpropanethioate.

Following general procedure from 2-phenyl-2H-benzo[d][1,3,2]dithiazole 1,1-dioxide (0.05 g,

0.2 mmol), (tert-butoxycarbonyl)-L-phenylalanine (0.05 g, 0.2 mmol) and either triphenylphosphine (0.05 g, 0.2 mmol) or triethylphosphite (0.03 mL, 0.2 mmol) was obtained clean thioester after purification by flash column chromatography on silica gel (3:1, hexanes:EtOAc). White solid (0.09 g, 0.18 mmol, 84 % yield from phosphine; 0.06 g, 0.13 mmol, 64 % yield from phosphite); m.p. 108 - 110 oC; 1H NMR (400 MHz); 13C NMR (101 MHz) 198.2, 156.4, 142.5, 139.3, 136.7, 135.2, 132.8, 131.1, 129.9, 129.1, 129.0, 128.9, 127.5, 125.9, 124.7, 121.2, 82.2, 62.2, 37.1, 28.5; HRMS (ESI) Calcd for C26H28N2O5S2 [M+H+]

–  –  –





S-(2-(N-(2,6-dimethylphenyl)sulfamoyl)phenyl) 2-((tert-butoxycarbonyl)amino)-3phenylpropanethioate. Following general procedure from 2-(2,6-dimethylphenyl)-2Hbenzo[d][1,3,2]dithiazole 1,1-dioxide (0.06 g, 0.2 mmol), (tert-butoxycarbonyl)-L-phenylalanine (0.05 g, 0.2 mmol) and either triphenylphosphine (0.05 g, 0.2 mmol) or triethylphosphite (0.03 mL, 0.2 mmol) was obtained clean thioester after purification by flash column chromatography on silica gel (4:1, hexanes:EtOAc). White solid (0.09 g, 0.17 mmol, 87 % yield from phosphine;

XX g, XX mmol, 66 % yield from phosphite); m.p. 97 - 98 oC; 1H NMR (400 MHz, CDCl3) δ 8.02 (dd, J = 7.8, 1.5 Hz, 1H), 7.61 (td, J = 7.5, 1.5 Hz, 1H), 7.56 – 7.46 (m, 2H), 7.38 – 7.25 (m, 3H), 7.23 – 7.16 (m, 2H), 7.05 (dd, J = 8.7, 6.2 Hz, 1H), 7.01 – 6.96 (m, 2H), 5.11 (d, J = 6.3 Hz, 1H), 4.47 (dt, J = 8.0, 5.8 Hz, 1H), 3.15 (qd, J = 14.2, 6.7 Hz, 2H), 2.09 (s, 6H), 1.40 (s, 9H); 13C NMR (101 MHz, CDCl3) δ 198.2, 155.9, 139.0, 138.4, 135.2, 133.8, 132.3, 129.9, 129.2, 129.0, 128.9, 128.7, 128.3, 127.7, 127.5, 125.5, 81.6, 61.8, 37.2, 28.3, 19.1; HRMS (ESI) Calcd for

–  –  –

S-(2-(N-isopropylsulfamoyl)-4-nitrophenyl) 2-((tert-butoxycarbonyl)amino)-3phenylpropanethioate. Following general procedure from 2-isopropyl-6-nitro-2Hbenzo[d][1,3,2]dithiazole 1,1-dioxide (0.05 g, 0.2 mmol), (tert-butoxycarbonyl)-L-phenylalanine (0.05 g, 0.2 mmol) and either triphenylphosphine (0.05 g, 0.2 mmol) or triethylphosphite (0.03 mL, 0.2 mmol) was obtained clean thioester after purification by flash column chromatography on silica gel (3:1, hexanes:EtOAc). Yellow solid (0.09 g, 0.17 mmol, 94 % yield from phosphine; 0.08 g, 0.16 mmol, 79 % yield from phosphite); m.p. 92 - 94 oC; 1H NMR (400 MHz, CDCl3) δ 8.94 (d, J = 2.5 Hz, 1H), 8.38 (dd, J = 8.4, 2.5 Hz, 1H), 7.63 (d, J = 8.4 Hz, 1H), 7.45 – 7.26 (m, 3H), 7.24 – 7.17 (m, 2H), 6.04 (d, J = 7.8 Hz, 1H), 5.17 (d, J = 5.6 Hz, 1H), 4.36 (dt, J = 8.9, 5.2 Hz, 1H), 3.51 (ddt, J = 13.0, 7.8, 6.5 Hz, 1H), 3.23 (dd, J = 14.2, 4.9 Hz, 1H), 3.14 (dd, J = 14.2, 8.9 Hz, 1H), 1.49 (s, 9H), 1.15 (d, J = 6.5 Hz, 3H), 0.90 (d, J = 6.5 Hz, 3H);

13 C NMR (101 MHz, CDCl3) δ 197.2, 156.2, 148.0, 146.6, 140.4, 134.9, 133.8, 129.2, 129.1, 127.7, 126.1, 124.5, 82.4, 62.4, 46.8, 36.9, 28.5, 23.8, 22.9; HRMS (ESI) Calcd for

–  –  –

S-(2-(N-(2,6-dimethylphenyl)sulfamoyl)-4-nitrophenyl) 2-((tert-butoxycarbonyl)amino)-3phenylpropanethioate. Following general procedure from 2-(2,6-dimethylphenyl)-6-nitro-2Hbenzo[d][1,3,2]dithiazole 1,1-dioxide (0.07 g, 0.2 mmol), (tert-butoxycarbonyl)-L-phenylalanine (0.05 g, 0.2 mmol) and either triphenylphosphine (0.05 g, 0.2 mmol) or triethylphosphite (0.03 mL, 0.2 mmol) was obtained clean thioester after purification by flash column chromatography on silica gel (3:1, hexanes:EtOAc). Yellow solid (0.09 g, 0.17 mmol, 86 % yield from phosphine; 0.08 g, 0.16 mmol, 61 % yield from phosphite); m.p. 112 - 113 oC; 1H NMR (400 MHz, CDCl3) δ 8.82 (d, J = 2.5 Hz, 1H), 8.43 (dd, J = 8.4, 2.5 Hz, 1H), 7.72 (d, J = 8.4 Hz, 1H), 7.57 (s, 1H), 7.43 – 7.28 (m, 3H), 7.25 – 7.18 (m, 2H), 7.10 (dd, J = 8.4, 6.5 Hz, 1H), 7.02 (d, J = 7.5 Hz, 2H), 5.15 (d, J = 6.0 Hz, 1H), 4.48 (dt, J = 7.6, 5.8 Hz, 1H), 3.27 – 3.12 (m, 2H), 2.08 (s, 6H), 1.42 (s, 9H); 13C NMR (100 MHz, CDCl3) δ 196.9, 156.2, 148.1, 147.6, 140.3, 138.3, 135.0, 134.0, 133.2, 129.3, 129.3, 128.7, 128.3, 127.9, 126.3, 123.8, 82.3, 62.3, 37.2, 28.4, 19.3;

HRMS (ESI) Calcd for C38H31N3O7S2 [M+H+] 586.1681, found 586.1701; IR (neat) 3383, 3216,

–  –  –

2-isopropyl-7-nitro-2,3-dihydrobenzo[e][1,4,2]dithiazine 1,1-dioxide. In a roundbottom flask, 2-(tert-butylthio)-N-isopropyl-5-nitrobenzenesulfonamide (1.00 g, 3.01 mmol), TMSCl (0.40 g,

3.31 mmol) and DMSO (0.26 g, 3.31 mmol) were taken up in chloroform and refluxed for 2 hours. Upon completion, hexane was added to the reaction until a precipitate formed. The solid was collected by filtration and recrystallized from ethanol and water to give clean product.

Yellow solid (0.59 g, 2.05 mmol, 68 % yield); m.p. 86 - 88 oC; 1H NMR (400 MHz, CDCl3) δ 8.76 (d, J = 2.6 Hz, 1H), 8.16 (dd, J = 9.2, 2.6 Hz, 1H), 7.37 (d, J = 9.2 Hz, 1H), 5.22 (s, 2H), 4.40 – 3.92 (m, 1H), 1.25 (d, J = 6.7 Hz, 6H); 13C NMR (100 MHz, CDCl3) δ 145.4, 144.5, 134.1, 129.1, 126.2, 121.4, 121.4, 52.1, 46.4, 20.9, 20.8; HRMS (ESI) Calcd for C10H12N2O4S2 [M+H+] 289.0317, found 289.0315; IR (neat) 3283 cm-1

General procedure for coupling of thioester with boronic acid:

To a dry round bottom flask was added thioester (1.1 equiv), boronic acid (2.5 equiv), copper(I) 3-methylsalicylate (10 mol %) and 4Å molecular sieves. Dry DMF was then added and the reaction was stirred at the appropriate temperature until completion as indicated by TLC. Over the course of the reaction the color of the solution changed from dark red to green. Upon completion, the reaction was diluted with diethyl ether and washed with 1M HCl (2x), saturated sodium bicarbonate (2x), and water (1x). The ether layer was then collected, dried with MgSO4, and concentrated to give crude product that was purified by column chromatography on silica gel

–  –  –

N-isopropyl-5-nitro-2-(pyrimidin-5-ylthio)benzenesulfonamide. Following general procedure from S-(2-(N-isopropylsulfamoyl)-4-nitrophenyl) 2-((tert-butoxycarbonyl)amino)-3phenylpropanethioate (0.04 g, 0.08 mmol), pyrimidine-5-boronic acid (0.03 g, 0.21 mmol), and copper(I) 3-methylsalicylate (0.9 mg, 0.008 mmol)) was obtained S-arylated BDT after purification by flash column chromatography on silica gel (2:1, hexanes:EtOAc). Yellow solid (0.021 g, 0.06 mmol, 72 % yield); m.p. 87 – 89 oC; 1H NMR (400 MHz, CDCl3) δ 9.32 (s, 1H), 8.93 – 8.79 (m, 3H), 8.17 (dd, J = 8.7, 2.5 Hz, 1H), 7.04 (d, J = 8.7 Hz, 1H), 5.22 (d, J = 7.9 Hz, 1H), 3.70 – 3.53 (m, 1H), 1.17 (d, J = 6.5 Hz, 6H); 13C NMR (100 MHz, CDCl3) δ 161.8, 159.2, 145.7, 143.3, 129.9, 129.4, 128.3, 126.8, 125.2, 46.9, 23.8; HRMS (ESI) calcd for C13H14N4O4S2

–  –  –

References (1) Zani, F.; Vicini, P.; Incerti, M. Eur. J. Med. Chem. 2004, 39 (2), 135–140.

(2) Zani, F.; Incerti, M.; Ferretti, R.; Vicini, P. Eur. J. Med. Chem. 2009, 44 (6), 2741–2747.

(3) Bravo, Y.; Teriete, P.; Dhanya, R.-P.; Dahl, R.; Lee, P. S.; Kiffer-Moreira, T.; Ganji, S.

R.; Sergienko, E.; Smith, L. H.; Farquharson, C.; Millán, J. L.; Cosford, N. D. P. Bioorg.

Med. Chem. Lett. 2014, 24 (17), 4308–4311.

(4) Dahl, R.; Bravo, Y.; Sharma, V.; Ichikawa, M.; Dhanya, R.-P.; Hedrick, M.; Brown, B.;

Rascon, J.; Vicchiarelli, M.; Mangravita-Novo, A.; Yang, L.; Stonich, D.; Su, Y.; Smith, L. H.; Sergienko, E.; Freeze, H. H.; Cosford, N. D. P. J. Med. Chem. 2011, 54 (10), 3661– 3668.

(5) Rice, W. G.; Supko, J. G.; Malspeis, L.; Buckheit, R. W.; Clanton, D.; Bu, M.; Graham, L.; Schaeffer, C. A.; Turpin, J. A.; Domagala, J.; Gogliotti, R.; Bader, J. P.; Halliday, S.

M.; Coren, L.; Sowder, R. C.; Arthur, L. O.; Henderson, L. E. Science 1995, 270 (5239), 1194–1197.

(6) Turpin, J. A.; Song, Y.; Inman, J. K.; Huang, M.; Wallqvist, A.; Maynard, A.; Covell, D.

G.; Rice, W. G.; Appella, E. J. Med. Chem. 1999, 42 (1), 67–86.

(7) Uhlendorf, joachim; Kuhl, peter; Leyck, sigurd. Benzo-1,3,2-dithiazole-1,1-dioxides, processes for their preparation, and their use as medicaments. DE3635696 (A1), April 28, 1988.

(8) Villalobos, J. M. Aerobic, Medal Mediated Ketone Synthesis from Thiol Esters and Boronic Acids. PhD, Emory University, 2007.

(9) Wright, S. W.; Abelman, M. M.; Bostrom, L. L.; Corbett, R. L. Tetrahedron Lett. 1992, 33 (2), 153–156.

(10) Wang, Z.; Kuninobu, Y.; Kanai, M. J. Org. Chem. 2013, 78 (14), 7337–7342.

(11) Shiau, T. P.; Erlanson, D. A.; Gordon, E. M. Org. Lett. 2006, 8 (25), 5697–5699.

(12) Sanchez, J. P. J. Heterocycl. Chem. 1997, 34 (5), 1463–1467.

(13) Li, Z.-S.; Wang, W.-M.; Lu, W.; Niu, C.-W.; Li, Y.-H.; Li, Z.-M.; Wang, J.-G. Bioorg.

Med. Chem. Lett. 2013, 23 (13), 3723–3727.

(14) Henke, A.; Srogl, J. J. Org. Chem. 2008, 73 (19), 7783–7784.

(15) Endo, T.; Ikenaga, S.; Mukaiyama, T. Bull. Chem. Soc. Jpn. 1970, 43 (8), 2632–2633.

(16) Villalobos, J. M.; Srogl, J.; Liebeskind, L. S. J. Am. Chem. Soc. 2007, 129 (51), 15734– 15735.

(17) Liebeskind, L. S.; Yang, H.; Li, H. Angew. Chem. Int. Ed. 2009, 48 (8), 1417–1421.

(18) Unpublished results from Matt Lindale.

(19) Savarin, C.; Srogl, J.; Liebeskind, L. S. Org. Lett. 2001, 3 (1), 91–93.

(20) Lam, L. Acylative Redox Dehydration of Carboxylic Acids and Benzoisothiazolones in the Synthesis of Thioesters with Triethylphosphite as a Terminal Reductant. MS, Emory University, 2015.

(21) Wagner, A. W.; Banholzer, R. Chem. Ber. 1963, 96 (4), 1177–1186.

(22) Sujit Ranjan Acharjee, S. R. A. IOSR J. Appl. Chem. 2013, 3 (6), 40–45.

(23) Correa, A.; Tellitu, I.; Domínguez, E.; SanMartin, R. Org. Lett. 2006, 8 (21), 4811–4813.

(24) Pan, L.; Jiang, Y.; Liu, Z.; Liu, X.-H.; Liu, Z.; Wang, G.; Li, Z.-M.; Wang, D. Eur. J.

Med. Chem. 2012, 50, 18–26.

(25) Shaw, A. N.; Tedesco, R.; Bambal, R.; Chai, D.; Concha, N. O.; Darcy, M. G.; Dhanak, D.; Duffy, K. J.; Fitch, D. M.; Gates, A.; Johnston, V. K.; Keenan, R. M.; Lin-Goerke, J.;

52

Liu, N.; Sarisky, R. T.; Wiggall, K. J.; Zimmerman, M. N. Bioorg. Med. Chem. Lett. 2009, 19 (15), 4350–4353.

(26) Varela-Álvarez, A.; Liebeskind, L. S.; Musaev, D. G. Organometallics 2012, 31 (22), 7958–7968.

(27) Cheng, B.; Yi, H.; He, C.; Liu, C.; Lei, A. Organometallics 2015, 34 (1), 206–211.

(28) Thomas, A. M.; Lin, B.-L.; Wasinger, E. C.; Stack, T. D. P. J. Am. Chem. Soc. 2013, 135 (50), 18912–18919.

(29) Sanz, R.; Aguado, R.; Pedrosa, M. R.; Arnáiz, F. J. Synthesis 2002, 2002 (07), 856–858.

Liwosz, T. W.; Chemler, S. R. Chem. – Eur. J. 2013, 19 (38), 12771–12777.

(30) (31) Posner, G. H.; Brunelle, D. J.; Sinoway, L. Synthesis 1974, 1974 (09), 662–663.

(32) Vrubel, H.; Hörner, M.; dos Reis Crespan, E.; Nakagaki, S.; Nunes, F. S. Z. Für Anorg.

Allg. Chem. 2008, 634 (11), 1839–1841.

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«1 HOSEA Hosea ministered in the years of Hezekiah, king of Judah and Jeroboam the Second, king of Israel. The Lord called Hosea by telling him to marry a woman of whoredom (1:2ff). This was in order that he and the readers could see how Israel and Judah had acted like whores, not faithful wives toward God. But God would not be denied a people to be his people; his people would ultimately come from the Gentiles of the world, not only the Jews (1:10; see Rom. 9:2426; Rom. 8:14). While Israel and...»

«Cardiac Department Cardiac Catheterisation Information for parents and carers You have recently been informed that your child requires a cardiac catheter. The information in this booklet aims to answer any questions you may have about the procedure and will cover the following main areas: What is a cardiac catheterisation?  Where will the catheterisation be performed?  Admission for catheterisation  Going home after cardiac catheterisation  Should you have any questions about any of...»





 
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