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«Meiosis and Fertilization – Understanding How Genes Are Inherited1 Almost all the cells in your body were produced by mitosis. The only exceptions ...»

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28. In most cases, an embryo which has an extra chromosome in each cell develops such severe abnormalities that the embryo dies, resulting in a miscarriage. For example, an extra copy of any of the chromosomes in the top row of the karyotype results in such severe abnormalities that the embryo always dies. In contrast, an extra copy of chromosome 21 results in less severe abnormalities so the embryo can often survive to be born as a baby with Down syndrome. What do you think is the reason why a third copy of chromosome 1, 2, 3, 4 or 5 results in more severe abnormalities than a third copy

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