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«COLLOIDAL GOLD NANOPARTICLES FOR CANCER THERAPY: EFFECTS OF PARTICLE SIZE ON TREATMENT EFFICACY, TOXICOLOGY, AND BIODISTRIBUTION A Dissertation ...»

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150. Tsen M, Sun L. Surface-enhanced Raman scattering from functionalized selfassembled monolayers: Part 1. Distance dependence of enhanced Raman scattering from a terminal phenyl group. Analytica Chimica Acta 1995;307(2Ye Q, Fang JX, Sun L. Surface-enhanced Raman scattering from functionalized self-assembled monolayers.2. Distance dependence of enhanced Raman scattering from an azobenzene terminal group. Journal of Physical Chemistry B 1997;101(41):8221-8224.

152. Loren A, Eliasson C, Josefson M, Murty K, Kall M, Abrahamsson J, et al.

Feasibility of quantitative determination of doxorubicin with surface-enhanced Raman spectroscopy. Journal of Raman Spectroscopy 2001 Nov;32(11):971-974.

153. Strekal N, German A, Gachko G, Maskevich A, Maskevich S. The study of the doxorubicin adsorbed onto chemically modified silver films by surface-enhanced spectroscopy. Journal of Molecular Structure 2001;563-564:183-191.

154. Yan Q, Priebe W, Chaires JB, Czernuszewicz RS. Interaction of doxorubicin and its derivatives with DNA: Elucidation by resonance Raman and surface-enhanced resonance Raman spectroscopy. Biospectroscopy 1997;3(4):307-316.

155. Sokolov K, Follen M, Aaron J, Pavlova I, Malpica A, Lotan R, et al. Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles. Cancer Research 2003;63(9):1999Willner D, Trail PA, Hofstead SJ, King HD, Lasch SJ, Braslawsky GR, et al. (6MALEIMIDOCAPROYL)HYDRAZONE OF DOXORUBICIN - A NEW

DERIVATIVE FOR THE PREPARATION OF IMMUNOCONJUGATES OF

DOXORUBICIN. Bioconjugate Chemistry 1993 Nov-Dec;4(6):521-527.

157. Ozeki T, Yuasa H, Kanaya Y. Control of medicine release from solid dispersion composed of the poly(ethylene oxide) carboxyvinylpolymer interpolymer complex by varying molecular weight of poly(ethylene oxide). Journal of Controlled Release 1999 Mar;58(1):87-95.

158. Costanzo PJ, Dan N, Lancaster KS, Lebrilla CB, Patten TE. Effect of changing polymer chain length on the target-mediated agglutination of polymer-grafted nanoparticles. Macromolecules 2008 Feb;41(4):1570-1576.

159. Kataoka K, Matsumoto T, Yokoyama M, Okano T, Sakurai Y, Fukushima S, et al.

Doxorubicin-loaded poly(ethylene glycol)-poly(beta-benzyl-l-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance. 5th Symposium on Controlled Drug Delivery; 1998 Apr 01-03;

Noordwijk Aan Zee, Netherlands; 1998. p. 143-153.

160. Gillies ER, Frechet JMJ. pH-responsive copolymer assemblies for controlled release of doxorubicin. Bioconjugate Chemistry 2005 Mar-Apr;16(2):361-368.

161. Jia Z, Wong L, Davis TP, Bulmus V. One-Pot Conversion of RAFT-Generated Multifunctional Block Copolymers of HPMA to Doxorubicin Conjugated Acidand Reductant-Sensitive Crosslinked Micelles. Biomacromolecules 2008;9(11):3106-3113.

162. Daniel M-C, Astruc D. Gold Nanoparticles: Assembly, Supramolecular Chemistry, Quantum-Size-Related Properties, and Applications toward Biology, Catalysis, and Nanotechnology. Chemical Reviews 2003;104(1):293-346.

163. Dixit V, Van den Bossche J, Sherman DM, Thompson DH, Andres RP. Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells. Bioconjugate Chemistry 2006 May;17(3):603-609.

164. Mukherjee P, Bhattacharya R, Mukhopadhyay D. Gold Nanoparticles Bearing Functional Anti-Cancer Drug and Anti-Angiogenic Agent: A "2 in 1" System with Potential Application in Cancer Therapeutics. Journal of Biomedical Nanotechnology 2005 Jun;1(2):224-228.

165. Podsiadlo P, Sinani VA, Bahng JH, Kam NWS, Lee J, Kotov NA. Gold nanoparticles enhance the anti-leukemia action of a 6-mercaptopurine chemotherapeutic agent. Langmuir 2008 Jan;24(2):568-574.

166. Chen YH, Tsai CY, Huang PY, Chang MY, Cheng PC, Chou CH, et al.

Methotrexate conjugated to gold nanoparticles inhibits tumor growth in a syngeneic lung tumor model. Molecular Pharmaceutics 2007 Sep-Oct;4(5):713Kang B, Mackey MA, El-Sayed MA. Nuclear targeting of gold nanoparticles in cancer cells induces DNA damage, causing cytokinesis arrest and apoptosis. J Am Chem Soc Feb 10;132(5):1517-1519.

168. Kaneko T, Willner D, Monkovic I, Knipe JO, Braslawsky GR, Greenfield RS, et al. New hydrazone derivatives of adriamycin and their immunoconjugates--a correlation between acid stability and cytotoxicity. Bioconjug Chem 1991 MayJun;2(3):133-141.

169. Hucknall A, Rangarajan S, Chilkoti A. In Pursuit of Zero: Polymer Brushes that Resist the Adsorption of Proteins. Advanced Materials 2009;21(23):2441-2446.

170. Chan Y-HM, Schweiss R, Werner C, Grunze M. Electrokinetic Characterization of Oligo- and Poly(ethylene glycol)-Terminated Self-Assembled Monolayers on Gold and Glass Surfaces. Langmuir 2003;19(18):7380-7385.

171. Herrwerth S, Eck W, Reinhardt S, Grunze M. Factors that Determine the Protein Resistance of Oligoether Self-Assembled Monolayers − Internal Hydrophilicity, Terminal Hydrophilicity, and Lateral Packing Density. Journal of the American Chemical Society 2003;125(31):9359-9366.

172. Heuberger M, Drobek T, Spencer ND. Interaction Forces and Morphology of a Protein-Resistant Poly(ethylene glycol) Layer. Biophysical Journal 2005;88(1):495-504.





173. Kreuzer HJr, Wang RLC, Grunze M. Hydroxide Ion Adsorption on SelfAssembled Monolayers. Journal of the American Chemical Society 2003;125(27):8384-8389.

174. Szleifer I. Polymers and proteins: interactions at interfaces. Current Opinion in Solid State and Materials Science 1997;2(3):337-344.

175. Jeon SI, Lee JH, Andrade JD, De Gennes PG. Protein--surface interactions in the presence of polyethylene oxide: I. Simplified theory. Journal of Colloid and Interface Science 1991;142(1):149-158.

176. Jain RK. Transport of Molecules, Particles, and Cells in Solid Tumors. Annual Review of Biomedical Engineering 1999;1(1):241-263.

177. Dreher MR, Chilkoti A. Toward a systems engineering approach to cancer drug delivery. J Natl Cancer Inst 2007 Jul 4;99(13):983-985.

178. Tang N, Du G, Wang N, Liu C, Hang H, Liang W. Improving Penetration in Tumors With Nanoassemblies of Phospholipids and Doxorubicin. Journal of the National Cancer Institute 2007 July 4, 2007;99(13):1004-1015.

179. Jain RKP, T. P. Lymphatics make the break. Science 2003;299(5604):209-210.

180. Padera TP, Kadambi A, di Tomaso E, Carrelra CM, Brown EB, Boucher Y, et al.

Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics.

Science 2002;296(5574):1883.

181. Swartz MA, Skobe M. Lymphatic function, lymphangiogenesis, and cancer metastasis. Microscopy Research and Technique 2001;55(2):92-99.

182. Jain RK, Baxter LT. Mechanisms of Heterogeneous Distribution of Monoclonal Antibodies and Other Macromolecules in Tumors: Significance of Elevated Interstitial Pressure. Cancer Research 1988 December 1, 1988;48(24 Part 1):7022-7032.

183. Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, et al.

Role of tumor-host interactions in interstitial diffusion of macromolecules:

Cranial vs. subcutaneous tumors. Proceedings of the National Academy of Sciences of the United States of America 2001 April 10, 2001;98(8):4628-4633.

184. Kirpotin DB, Drummond DC, Shao Y, Shalaby MR, Hong K, Nielsen UB, et al.

Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization but Does Increase Internalization in Animal Models. Cancer Research 2006 July 1, 2006;66(13):6732-6740.

185. Iyer AK, Khaled G, Fang J, Maeda H. Exploiting the enhanced permeability and retention effect for tumor targeting. Drug Discovery Today 2006;11(17-18):812Tabata Y, Kawai T, Murakami Y, Ikada Y. Electric Charge Influence of Dextran Derivatives on their Tumor Accumulation After Intravenous Injection. Drug Delivery 1997;4(3):213-221.

187. Takakura Y, Atsumi R, Hashida M, Sezaki H. Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with anionic charge. II.

Disposition and pharmacokinetics following intravenous and intramuscular administration. International Journal of Pharmaceutics 1987;37(1-2):145-154.

188. Michel CC, Curry FE. Microvascular Permeability. Physiological Reviews 1999 July 1, 1999;79(3):703-761.

189. Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, et al.

Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Nat Med 2005;11(6):678-682.

190. Kimura NT, Taniguchi Si, Aoki K, Baba T. Selective Localization and Growth of Bifidobacterium bifidum in Mouse Tumors following Intravenous Administration.

Cancer Research 1980 June 1, 1980;40(6):2061-2068.

191. Dvorak AM, Feng D. The Vesiculo-Vacuolar Organelle (VVO): A New Endothelial Cell Permeability Organelle. Journal of Histochemistry & Cytochemistry 2001 April 1, 2001;49(4):419-431.

192. Charrois GJR, Allen TM. Rate of biodistribution of STEALTH® liposomes to tumor and skin: influence of liposome diameter and implications for toxicity and therapeutic activity. Biochimica et Biophysica Acta (BBA) - Biomembranes 2003;1609(1):102-108.

193. Charrois GJR, Allen TM. Drug release rate influences the pharmacokinetics, biodistribution, therapeutic activity, and toxicity of pegylated liposomal doxorubicin formulations in murine breast cancer. Biochimica et Biophysica Acta (BBA) - Biomembranes 2004;1663(1-2):167-177.

194. Pirollo KF, Chang EH. Does a targeting ligand influence nanoparticle tumor localization or uptake? Trends in Biotechnology 2008;26(10):552-558.

195. Choi CHJ, Alabi CA, Webster P, Davis ME. Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles. Proceedings of the National Academy of Sciences 2010 January 19, 2010;107(3):1235-1240.

196. McNeeley KM, Annapragada A, Bellamkonda RV. Decreased circulation time offsets increased efficacy of PEGylated nanocarriers targeting folate receptors of glioma. Nanotechnology 2007;18(38):385101.

197. Goel R, Shah N, Visaria R, Paciotti GF, Bischof JC. Biodistribution of TNFalpha-coated gold nanoparticles in an in vivo model system. Nanomedicine (Lond) 2009 Jun;4(4):401-410.

198. Chen Y-S, Hung Y-C, Liau I, Huang G. Assessment of the In Vivo Toxicity of Gold Nanoparticles. Nanoscale Research Letters 2009;4(8):858-864.

199. Cho WS, Cho M, Jeong J, Choi M, Cho HY, Han BS, et al. Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles. Toxicol Appl Pharmacol 2009 Apr 1;236(1):16-24.

200. Torchilin VP. Nanoparticulates as Drug Carriers. London: Imperial College Press, 2006.

201. Storm G, Belliot SO, Daemen T, Lasic DD. Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system. Advanced Drug Delivery Reviews 1995;17(1):31-48.

202. Balasubramanian SK, Jittiwat J, Manikandan J, Ong C-N, Yu LE, Ong W-Y.

Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats. Biomaterials;31(8):2034-2042.

203. Bergen JM, von Recum HA, Goodman TT, Massey AP, Pun SH. Gold nanoparticles as a versatile platform for optimizing physicochemical parameters for targeted drug delivery. Macromol Biosci 2006 Jul 14;6(7):506-516.

204. Sadauskas E, Danscher G, Stoltenberg M, Vogel U, Larsen A, Wallin H.

Protracted elimination of gold nanoparticles from mouse liver. Nanomedicine 2009 Jun;5(2):162-169.

205. Semmler-Behnke M, Kreyling WG, Lipka J, Fertsch S, Wenk A, Takenaka S, et al. Biodistribution of 1.4- and 18-nm Gold Particles in Rats. Small 2008;4(12):2108-2111.

206. Kira A, Kim H, Yasuda K. Contribution of Nanoscale Curvature to Number Density of Immobilized DNA on Gold Nanoparticles. Langmuir 2009;25(3):1285-1288.

207. Gabizon A, Horowitz AT, Goren D, Tzemach D, Shmeeda H, Zalipsky S. In Vivo Fate of Folate-Targeted Polyethylene-Glycol Liposomes in Tumor-Bearing Mice.

Clinical Cancer Research 2003 December 15, 2003;9(17):6551-6559.

208. Smith RW, Leppard B, Barnett NL, Millward-Sadler GH, McCrae F, Cawley MID. Chrysiasis revisited: a clinical and pathological study. British Journal of Dermatology 1995;133(5):671-678.

209. Sonavane G, Tomoda K, Sano A, Ohshima H, Terada H, Makino K. In vitro permeation of gold nanoparticles through rat skin and rat intestine: Effect of particle size. Colloids and Surfaces B: Biointerfaces 2008;65(1):1-10.

210. Cho WS, Cho M, Jeong J, Choi M, Han BS, Shin HS, et al. Size-dependent tissue kinetics of PEG-coated gold nanoparticles. Toxicol Appl Pharmacol 2010 May 15;245(1):116-123.

211. Deng X, Jia G, Wang H, Sun H, Wang X, Yang S, et al. Translocation and fate of multi-walled carbon nanotubes in vivo. Carbon 2007;45(7):1419-1424.

212. Yang RSH, Chang LW, Wu J-P, Tsai M-H, Wang H-J, Kuo Y-C, et al. Persistent

Tissue Kinetics and Redistribution of Nanoparticles, Quantum Dot 705, in Mice:

ICP-MS Quantitative Assessment. Environ Health Perspect 2007;115(9).

213. Jain TK, Reddy MK, Morales MA, Leslie-Pelecky DL, Labhasetwar V.

Biodistribution, Clearance, and Biocompatibility of Iron Oxide Magnetic Nanoparticles in Rats. Molecular Pharmaceutics 2008;5(2):316-327.

214. Lasagna-Reeves C, Gonzalez-Romero D, Barria MA, Olmedo I, Clos A, Sadagopa Ramanujam VM, et al. Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice. Biochemical and Biophysical Research Communications 2010;393(4):649-655.

215. Garnett MC, Kallinteri P. Nanomedicines and nanotoxicology: some physiological principles. Occupational Medicine 2006 August 2006;56(5):307Cedervall T, Lynch I, Foy M, Berggård T, Donnelly SC, Cagney G, et al. Detailed Identification of Plasma Proteins Adsorbed on Copolymer Nanoparticles.

Angewandte Chemie International Edition 2007;46(30):5754-5756.

217. Longmire M, Choyke PL, Kobayashi H. Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats.

Nanomedicine 2008;3(5):703-717.

218. Guyton ACH, J.E. Textbook of Medical Physiology. 11TH ed. Philadelphia:

Elsevier Saunders Publisher, 2006.

219. Renaud G, Hamilton RL, Havel RJ. Hepatic metabolism of colloidal gold-lowdensity lipoprotein complexes in the rat: Evidence for bulk excretion of lysosomal contents into bile. Hepatology 1989;9(3):380-392.

220. Hardonk MJ, Harms G, Koudstaal J. Zonal heterogeneity of rat hepatocytes in the in vivo uptake of 17 nm colloidal gold granules. Histochemistry and Cell Biology 1985;83(5):473-477.

221. Pan D, Pramanik M, Senpan A, Ghosh S, Wickline SA, Wang LV, et al. Near infrared photoacoustic detection of sentinel lymph nodes with gold nanobeacons.

Biomaterials 2010 May;31(14):4088-4093.

222. Videira MA, Botelho MF, Santos AC, Gouveia LF, Pedroso de Lima JJ, Almeida AnJ. Lymphatic Uptake of Pulmonary Delivered Radiolabelled Solid Lipid Nanoparticles. Journal of Drug Targeting 2002;10(8):607-613.

223. Videira MA, Gano L, Santos C, Neves M, Almeida AJ. Lymphatic uptake of lipid nanoparticles following endotracheal administration. Journal of Microencapsulation 2006;23(8):855-862.

224. Iwai K, Maeda H, Konno T. Use of oily contrast medium for selective drug targeting to tumor: enhanced therapeutic effect and X-ray image. Cancer Res 1984 May;44(5):2115-2121.

225. Iwai K, Maeda H, Konno T, Matsumura Y, Yamashita R, Yamasaki K, et al.

Tumor targeting by arterial administration of lipids: rabbit model with VX2 carcinoma in the liver. Anticancer Res 1987 May-Jun;7(3 Pt B):321-327.

226. www.doxil.com.

227. www.ClinicalTrials.gov.

228. Barenholz Y. Liposome application: problems and prospects. Current Opinion in Colloid & Interface Science 2001;6(1):66-77.

229. Gabizon A, Shmeeda H, Barenholz Y. Pharmacokinetics of Pegylated Liposomal Doxorubicin: Review of Animal and Human Studies. Clinical Pharmacokinetics 2003;42(5):419-436.

230. Plosker GL. Pegylated Liposomal Doxorubicin: A Review of its Use in the Treatment of Relapsed or Refractory Multiple Myeloma. Drugs 2008;68(17):2535-2551.

231. Petrelli F, Borgonovo K, Barni S. Targeted delivery for breast cancer therapy: the history of nanoparticle-albumin-bound paclitaxel. Expert Opinion on Pharmacotherapy 2010;11(8):1413-1432.

232. www.abraxane.com.

–  –  –

Kate Lee was born in Seoul, South Korea. Due to her dad’s job, Kate Lee spent most of her childhood in Yangon, Myanmar, where she attended International School of Yangon. Later in her teens, she again moved with her family to Houston, Texas. She received her B.S. degree in Chemical Engineering at the University of Texas at Austin in

2004. After graduation, Kate joined a business consulting firm called Accenture and worked as an analyst for one year. Due to her passion in biomedical engineering, Kate decided to pursue her Ph.D. degree at Georgia Institute of Technology. She once visited Georgia Institute of Technology as an undergraduate for a summer research program and was impressed with the deparment. Apart from research, Kate loves to go to the gym where she is actively involved in cardio kickboxing, boxing, yoga, and boot camp classes. Kate enjoys singing and dancing. Kate also loves to travel and try different food

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